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1

MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study

Ambery, Philip, Parker, Victoria E, Stumvoll, Michael, Posch, Maximilian G, Heise, Tim, Plum-Moerschel, Leona, Tsai, Lan-Feng, Robertson, Darren, Jain, Meena, Petrone, Marcella, Rondinone, Cristina, H

Journal:

Lancet (London, England)

Année:

2018

Langue:

english

Fichier:

PDF, 360 KB

english, 2018

2

The relevance of socio-demographic and occupational variables for the assessment of work-related stress risk

Marinaccio, Alessandro, Ferrante, Pierpaolo, Corfiati, Marisa, Di Tecco, Cristina, Rondinone, Bruna M, Bonafede, Michela, Ronchetti, Matteo, Persechino, Benedetta, Iavicoli, Sergio

Journal:

BMC Public Health

Année:

2013

Langue:

english

Fichier:

PDF, 216 KB

english, 2013

3

Work-Related Stress Risk Assessment in Italy: A Methodological Proposal Adapted to Regulatory Guidelines

Persechino, Benedetta, Valenti, Antonio, Ronchetti, Matteo, Rondinone, Bruna Maria, Di Tecco, Cristina, Vitali, Sara, Iavicoli, Sergio

Journal:

Safety and Health at Work

Année:

2013

Langue:

english

Fichier:

PDF, 189 KB

english, 2013

4

Anti-Inflammatory activity of 11β-hydroxypregna-1,4-diene-3,20-dione

Cristina M. Rondinone, Roxana Schillaci, Alicia Roldán

Journal:

Drug Development Research

Année:

1992

Langue:

english

Fichier:

PDF, 309 KB

english, 1992

5

Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes

Águeda González-Rodriguez, Óscar Escribano, Javier Alba, Cristina M. Rondinone, Manuel Benito, Ángela M. Valverde

Journal:

Journal of Cellular Physiology

Année:

2007

Langue:

english

Fichier:

PDF, 587 KB

english, 2007

6

PTP1B deficiency enhances liver growth during suckling by increasing the expression of insulin-like growth factor-I

Fernando Escrivá, Águeda González-Rodriguez, Elisa Fernández-Millán, Cristina M. Rondinone, Carmen Álvarez, Ángela M. Valverde

Journal:

Journal of Cellular Physiology

Année:

2010

Langue:

english

Fichier:

PDF, 342 KB

english, 2010

7

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

Mei Liu, Sanyi Wang, Jill E. Clampit, Rebecca J. Gum, Deanna L. Haasch, Cristina M. Rondinone, James M. Trevillyan, Cele Abad-Zapatero, Elizabeth H. Fry, Hing L. Sham, Gang Liu

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 249 KB

english, 2007

8

On the Control of Lipolysis in Adipocytes

CONSTANTINE LONDOS, DAWN L. BRASAEMLE, CHARLES J. SCHULTZ, DIANE C. ADLER-WAILES, DANIEL M. LEVIN, ALAN R. KIMMEL, CRISTINA M. RONDINONE

Journal:

Annals of the New York Academy of Sciences

Année:

1999

Langue:

english

Fichier:

PDF, 569 KB

english, 1999

9

Role of insulin-like growth factor-1 on the kinetics of human lymphocytes stimulation in serum-free culture medium

Schillaci, Roxana, Ribaudo, Claudia M, Rondinone, Cristina M, Roldán, Alicia

Journal:

Immunology & Cell Biology

Année:

1994

Langue:

english

Fichier:

PDF, 2.89 MB

english, 1994

10

Insulin resistance in fat cells from obese Zucker rats - Evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4

Eugénia Carvalho, Cristina Rondinone, Ulf Smith

Journal:

Molecular and Cellular Biochemistry

Année:

2000

Langue:

english

Fichier:

PDF, 550 KB

english, 2000

11

Adipocyte-derived hormones, cytokines, and mediators

Cristina M. Rondinone

Journal:

Endocrine (Springer)

Année:

2006

Langue:

english

Fichier:

PDF, 247 KB

english, 2006

12

[Methods in Molecular Biology™] Therapeutic Applications of RNAi ||

Rondinone, Cristina M., Reidhaar-Olson, John F.

Année:

2009

Langue:

english

Fichier:

PDF, 212 KB

english, 2009

13

Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli

Soledad Miranda, Águeda González-Rodríguez, Jesús Revuelta-Cervantes, Cristina M. Rondinone, Ángela M. Valverde

Journal:

Cellular Signalling

Année:

2010

Langue:

english

Fichier:

PDF, 6.24 MB

english, 2010

14

[Methods in Molecular Biology™] Therapeutic Applications of RNAi Volume 555 || Transcriptional Gene Silencing Using Small RNAs

Rondinone, Cristina M., Reidhaar-Olson, John F.

Année:

2009

Langue:

english

Fichier:

PDF, 193 KB

english, 2009

15

PKB Inhibition Prevents the Stimulatory Effect of Insulin on Glucose Transport and Protein Translocation but Not the Antilipolytic Effect in Rat Adipocytes

Ulf Smith, Eugenia Carvalho, Erifili Mosialou, Francesco Beguinot, Pietro Formisano, Cristina Rondinone

Journal:

Biochemical and Biophysical Research Communications

Année:

2000

Langue:

english

Fichier:

PDF, 282 KB

english, 2000

16

Regulation of Proteins Involved in Insulin Signaling Pathways in Differentiating Human Adipocytes

Terry Pederson, Cristina M. Rondinone

Journal:

Biochemical and Biophysical Research Communications

Année:

2000

Langue:

english

Fichier:

PDF, 322 KB

english, 2000

17

Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation

Christian J Carlson, Morris F White, Cristina M Rondinone

Journal:

Biochemical and Biophysical Research Communications

Année:

2004

Langue:

english

Fichier:

PDF, 1.83 MB

english, 2004

18

Reduction of PTP1B induces differential expression of PI3-kinase (p85α) isoforms

Cristina M. Rondinone, Jill Clampit, Rebecca J. Gum, Bradley A. Zinker, Michael R. Jirousek, James M. Trevillyan

Journal:

Biochemical and Biophysical Research Communications

Année:

2004

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2004

19

PKCθ is a key player in the development of insulin resistance

Deanna Haasch, Cathleen Berg, Jill E. Clampit, Terry Pederson, Leigh Frost, Paul Kroeger, Cristina M. Rondinone

Journal:

Biochemical and Biophysical Research Communications

Année:

2006

Langue:

english

Fichier:

PDF, 190 KB

english, 2006

20

Rapamycin partially prevents insulin resistance induced by chronic insulin treatment

Cathleen E Berg, Brian E Lavan, Cristina M Rondinone

Journal:

Biochemical and Biophysical Research Communications

Année:

2002

Langue:

english

Fichier:

PDF, 194 KB

english, 2002

21

Proteasome inhibitors regulate tyrosine phosphorylation of IRS-1 and insulin signaling in adipocytes

Cristina M Rondinone, Deborah Kramer

Journal:

Biochemical and Biophysical Research Communications

Année:

2002

Langue:

english

Fichier:

PDF, 255 KB

english, 2002

22

Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells

Jill E Clampit, Joseph L Meuth, Harriet T Smith, Regina M Reilly, Michael R Jirousek, James M Trevillyan, Cristina M Rondinone

Journal:

Biochemical and Biophysical Research Communications

Année:

2003

Langue:

english

Fichier:

PDF, 292 KB

english, 2003

23

The inhibitory effect of staurosporine on insulin action is prevented by okadaic acid. Evidence for an important role of serine/threonine phosphorylation in eliciting insulin-like effects

Cristina M Rondinone, Mary-Jane Zarnowski, Constantine Londos, Ulf P.G Smith

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

1996

Langue:

english

Fichier:

PDF, 750 KB

english, 1996

24

Fatty acid modulators for the treatment of diabesity

Stanley J. Wertheimer, David Bolin, Shawn Erickson, Karin Conde-Knape, Charles Belunis, Anish Konkar, Rebecca Taub, Cristina M. Rondinone

Journal:

Drug Discovery Today: Therapeutic Strategies

Année:

2007

Langue:

english

Fichier:

PDF, 370 KB

english, 2007

25

Endothelin antagonism improves hepatic insulin sensitivity associated with insulin signaling in Zucker fatty rats

Nathalie Berthiaume, Christian J. Carlson, Cristina M. Rondinone, Bradley A. Zinker

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 479 KB

english, 2005

26

Pharmacological inhibition of p38 MAP kinase results in improved glucose uptake in insulin-resistant 3T3-L1 adipocytes

Christian J. Carlson, Cristina M. Rondinone

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 272 KB

english, 2005

27

[Methods in Molecular Biology™] Therapeutic Applications of RNAi Volume 555 || Liposomal siRNA for Ovarian Cancer

Rondinone, Cristina M., Reidhaar-Olson, John F.

Année:

2009

Langue:

english

Fichier:

PDF, 511 KB

english, 2009

28

Progestins stimulate the differentiation of 3T3-L1 preadipocytes

Rondinone, Cristina M., Baker, Michael E., Rodbard, David

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Année:

1992

Langue:

english

Fichier:

PDF, 849 KB

english, 1992

29

Insulin Receptor Substrate (IRS) 1 is Reduced and IRS-2 is the Main Docking Protein for Phosphatidylinositol 3-Kinase in Adipocytes from Subjects with Non-Insulin-Dependent Diabetes Mellitus

Cristina M. Rondinone, Ling-Mei Wang, Peter Lonnroth, Christian Wesslau, Jacalyn H. Pierce and Ulf Smith

Journal:

Proceedings of the National Academy of Sciences

Année:

1997

Langue:

english

Fichier:

PDF, 1.16 MB

english, 1997

30

[Methods in Molecular Biology™] Therapeutic Applications of RNAi Volume 555 || Development and Application of a Dual-Purpose Nanoparticle Platform for Delivery and Imaging of siRNA in Tumors

Rondinone, Cristina M., Reidhaar-Olson, John F.

Année:

2009

Langue:

english

Fichier:

PDF, 416 KB

english, 2009

31

[Methods in Molecular Biology™] Therapeutic Applications of RNAi Volume 555 || RNAi Using a Chitosan/siRNA Nanoparticle System: In Vitro and In Vivo Applications

Rondinone, Cristina M., Reidhaar-Olson, John F.

Année:

2009

Langue:

english

Fichier:

PDF, 212 KB

english, 2009

32

The emerging role of the intestine in metabolic diseases

Bradley, William D., Zwingelstein, Catherine, Rondinone, Cristina M.

Journal:

Archives of Physiology and Biochemistry

Année:

2011

Langue:

english

Fichier:

PDF, 851 KB

english, 2011

33

Kinase-dependent pathways and the development of insulin resistance in hepatocytes

Rondinone, Cristina M

Journal:

Expert Review of Endocrinology & Metabolism

Année:

2007

Langue:

english

Fichier:

PDF, 361 KB

english, 2007

34

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

Gustafson, Birgit, Hammarstedt, Ann, Hedjazifar, Shahram, Hoffmann, Jenny M., Svensson, Per-Arne, Grimsby, Joseph, Rondinone, Cristina, Smith, Ulf

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 2.37 MB

english, 2015

35

Serine Kinases as New Drug Targets for the Treatment of Type 2 Diabetes

Rondinone, Cristina

Journal:

Current Medicinal Chemistry - Immunology Endocrine & Metabolic Agents

Année:

2005

Langue:

english

Fichier:

PDF, 116 KB

english, 2005

36

Developmental Switch from Prolonged Insulin Action to Increased Insulin Sensitivity in Protein Tyrosine Phosphatase 1B-Deficient Hepatocytes

Gonzalez-Rodriguez, Agueda, Clampit, Jill E., Escribano, Oscar, Benito, Manuel, Rondinone, Cristina M., Valverde, Angela M.

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 847 KB

english, 2007

37

Minireview: Ribonucleic Acid Interference for the Identification of New Targets for the Treatment of Metabolic Diseases

Rondinone, Cristina M.

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 217 KB

english, 2006

38

RNAi: for functional analysis and target validation

Rondinone, Cristina M

Journal:

Expert Opinion on Therapeutic Targets

Année:

2006

Langue:

english

Fichier:

PDF, 281 KB

english, 2006

39

Diabetes: the latest developments in inhibitors, insulin sensitisers, new drug targets and novel approaches

Rondinone, Cristina M

Journal:

Expert Opinion on Therapeutic Targets

Année:

2005

Langue:

english

Fichier:

PDF, 63 KB

english, 2005

40

Genetic association meets RNA interference: large-scale genomic screens for causation and mechanism of complex diseases

Martin, Mitchell, Reidhaar-Olson, John F, Rondinone, Cristina M

Journal:

Pharmacogenomics

Année:

2007

Langue:

english

Fichier:

PDF, 292 KB

english, 2007

41

RNA interference to target lipid disorders

Rondinone, Cristina M

Journal:

Current Opinion in Lipidology

Année:

2008

Langue:

english

Fichier:

PDF, 119 KB

english, 2008

42

Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling

Galon-Tilleman, Hadas, Yang, Hong, Bednarek, Maria A., Spurlock, Sandra M., Paavola, Kevin J., Ko, Brian, To, Carmen, Luo, Jian, Tian, Hui, Jermutus, Lutz, Grimsby, Joseph, Rondinone, Cristina M., Kon

Journal:

Journal of Biological Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2017

43

MEDI0382, a GLP-1-glucagon receptor dual agonist, meets safety and tolerability endpoints in a single-dose, healthy-subject, randomised, phase 1 study

Ambery, Philip D., Klammt, Sebastian, Posch, Maximillian G., Petrone, Marcella, Pu, Wenji, Rondinone, Cristina, Jermutus, Lutz, Hirshberg, Boaz

Journal:

British Journal of Clinical Pharmacology

Année:

2018

Langue:

english

Fichier:

PDF, 524 KB

english, 2018

44

Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes

Boland, Brandon B., Brown, Charles, Boland, Michelle L., Cann, Jennifer, Sulikowski, Michael, Hansen, Gitte, Grønlund, Rikke V., King, Wanda, Rondinone, Cristina, Trevaskis, James, Rhodes, Christopher

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2018

45

Therapeutic potential of RNAi in metabolic diseases

Rondinone, Cristina M.

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 439 KB

english, 2006

46

Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM

CARVALHO, EUGENIA, JANSSON, PER-ANDERS, AXELSEN, METTE, ERIKSSON, JAN W., HUANG, XUDONG, GROOP, LEIF, RONDINONE, CRISTINA, SJÖSTRÖM, LARS, SMITH, ULF

Journal:

The FASEB Journal

Année:

1999

Langue:

english

Fichier:

PDF, 217 KB

english, 1999